Review
Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis
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- PMID: 1964049
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Review
Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis
Neuropsychopharmacology.
1990 Oct-Dec.
Abstract
Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic administration of antagonists elicits a paradoxical downregulation of both receptors. This article explores the possible explanations for these anomalous findings.
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