[Content of the components of the adenylic acid system in solid and ascitic tumors in the liver of experimental animals]

Abstract

The authors report the results of separate determination of the concentration of free adenine nucleotides (ATP, ADP, AMP) in tumors, intact animals liver, and tumor-bearing animals liver. In Zajdela ascites hepatoma, ascites tumor NKly and solid lymphosarcoma, solid hepatomas 46 and 22 A the amount of ATP and ADP was found to be markedly reduced compared with their content in the liver. The ratio ATP/ADP is increased in ascites cells of tumor NKly, Zaidela hepatoma and lymphosarcoma and is decreased in solid hepatoma 46 and 22 A. Cell energy potential, calculated on the basis of ATP ratio to a sum of adenine-nucleotides, is also increased in ascites cells of tumor NKly, Zaidela hepatoma and is diminished or remains unchanged in hepatoma 46 or 22A. Cell energy charge is increased in tumor NKly, Zajdela hepatoma, lymphosarcoma and is decreased in solid hepatoma 46 and 22A.