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Comparative Study
. 2009 May-Jun:(3):28-33.

[Carcinogenic hazard of chloroform and other drinking water chlorination by-products]

[Article in Russian]
I A Chernichenko, N V Balenko, O N Litvichenko
  • PMID: 19642551
Comparative Study

[Carcinogenic hazard of chloroform and other drinking water chlorination by-products]

[Article in Russian]
I A Chernichenko et al. Gig Sanit. 2009 May-Jun.

Abstract

The paper presents the results of studying the carcinogenic effect of chloroform and its combination with carbon tetrachloride, 1,2-dichloroethane, trichloroethylene during chronic oral administration to F1(CBAxC57Bl6) mice. There is a relationship between the manifestation of carcinogenesis to the dose of chloroform and a combination of chemicals, as well as its enhancement upon exposure to the combination as compared with acute administration of chloroform. Exposure to a combination of substances at the level of their maximum permissible concentrations does not affect carcinogenesis. The possible mechanisms of the specific features of carcinogenesis in this experiment are discussed.

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