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Review
. 2010 Feb;9(4):195-9.
doi: 10.1016/j.autrev.2009.07.004. Epub 2009 Jul 27.

Malignancies in systemic lupus erythematosus

Emese Kiss  1 , Laszlo Kovacs, Peter Szodoray
Affiliations
Review

Malignancies in systemic lupus erythematosus

Emese Kiss et al. Autoimmun Rev. 2010 Feb.

Abstract

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease, characterized by a wide array of symptoms and organ involvements, leading to varying disease courses and outcome, and ranging from mild to severe types. In patients with SLE, the incidence and risk of malignancy development is increased, and mostly non-Hodgkin's lymphoma (NHL), cervical cancer, as well as bronchial carcinomas occur. Besides others, the common genetic predisposition, chronic antigen stimulus, disproportional immune responses, as well as the chronic administration of immunosuppressive medications can contribute to the development of malignancies in lupus. In this review we present the molecular pathology, as well as the epidemiological and clinical aspects of malignancies in patients with SLE.

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