Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Sep;94(4):1212-1217.
doi: 10.1016/j.fertnstert.2009.06.039. Epub 2009 Jul 30.

The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer

Constanze Banz  1 , Ute Ungethuem  2 , Ralf-Juergen Kuban  3 , Klaus Diedrich  1 , Ernst Lengyel  4 , Daniela Hornung  5
Affiliations
Comparative Study

The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer

Constanze Banz et al. Fertil Steril. 2010 Sep.

Abstract

Objective: To determine whether endometriosis-associated endometrioid cancer (EAOC) is a specific entity compared with endometrioid cancer not associated with endometriosis (OC).

Design: Case-control study.

Setting: University hospital research laboratory.

Patient(s): Seven patients with endometriosis-associated ovarian cancer EAOC and five patients each with OC, ovarian endometriosis, and benign ovaries.

Intervention(s): Ovarian tissue samples were collected from surgical procedures.

Main outcome measure(s): We hybridized cRNA samples to the Affymetrix HG-U133A microarray chip. Representative genes were validated by real time polymerase chain reaction.

Result(s): We identified two main groups of genes: The first group contained the genes SICA2, CCL14, and TDGF1. These genes were equally regulated in endometriosis and EAOC but not in OC and benign ovaries. The second group contained the genes StAR, SPINT1, Keratin 8, FoxM1B, FOLR1, CRABP1, and Claudin 7. They were equally regulated in EAOC and OC but not in ovarian endometriosis and benign ovaries.

Conclusion(s): That the first group is composed of the cytokines SICA2 and CCL14 and the growth factor TDGF1 indicates that the regulation of the autoimmune system and of inflammatory cytokines may be very important in the etiology of endometriosis and EAOC. That the second group is composed of genes that play a central role in cell-cell interaction, differentiation, and cell proliferation indicates that they may be important in the development of ovarian cancer in women with endometriosis.

PubMed Disclaimer

References

    1. Rice VM. Conventional medical therapies for endometriosis. Ann N Y Acad Sci. 2002;955:343–352. - PubMed
    1. Coxhead D, Thomas EJ. The familial inheritance of endometriosis in a British population: a case control study. J Obstet Gynaecol. 1993;13:42–44.
    1. Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE, et al. Ovarian cancer risk associated with varying causes of infertility. Fertil Steril. 2004;82:405–414. - PubMed
    1. Clement PB, Seidman JD, Russell P, Kurman RJ. Diseases of the peritoneum. In: Kurman RJ, editor. Blaustein’s pathology of the female genital tract. 5th ed. New York: Springer; 2002. pp. 746–768.pp. 791–905.
    1. Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001;20:133–139. - PubMed