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Editorial
. 2009 Jul 31;105(3):209-10.
doi: 10.1161/CIRCRESAHA.109.202986.

NADPH oxidase 4: walking the walk with Poldip2

Francis J Miller Jr
Editorial

NADPH oxidase 4: walking the walk with Poldip2

Francis J Miller Jr. Circ Res. .
No abstract available

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Figures

Figure
Figure
Association of Poldip2 with Nox4 increases ROS generation and strengthens focal adhesions and stress fiber formation in SMCs. The dissociation of Poldip2 and Nox4 at the trailing edge of a migrating cell is predicted to release adhesions, whereas the association of Poldip2 with Nox4 at the leading edge increases adhesions. The dynamic regulation of focal adhesions by Nox4-Poldip2 may be important for directional cell migration. The role of Nox4-Poldip2 in the nucleus is unknown.
See this image and copyright information in PMC

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References

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