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. 1977 Jul 1;55(13):647-9.
doi: 10.1007/BF01482535.

[Hemodynamic changes after angiotensin II blockade by saralasin (author's transl)]

[Article in German]
G Liebau, J Beyer, D Larbig, K Schick, G Sekanina, K Hayduk

[Hemodynamic changes after angiotensin II blockade by saralasin (author's transl)]

[Article in German]
G Liebau et al. Klin Wochenschr. .

Abstract

Saralasin, an angiotensin II inhibitor was infused in 10 hypertensive patients. A blood pressure reduction was achieved after stimulation of the renin-angiotensin-system by salt depletion. Heart rate and cardiac output failed to compensate for reduction of blood pressure. Thus circulatory reflex-mechanisms are inhibited by saralasin. A direct influence on baroreceptor mechanism and/or catecholamines is probable. Failure of the hypotensive effect of saralasin in salt-depleted patients after administration of beta-blockers supports this hypothesis.

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References

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