doi: 10.1021/np900168d.
Steroidal glycosides from Agave utahensis and their cytotoxic activity
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- PMID: 19645463
- DOI: 10.1021/np900168d
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Steroidal glycosides from Agave utahensis and their cytotoxic activity
J Nat Prod.
2009 Aug.
Abstract
Eight new spirostanol saponins (1-8) and three new furostanol saponins (9-11) were isolated from the whole plants of Agave utahensis. The structures of 1-11 were determined by analysis of extensive spectroscopic data. The saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 showed cytotoxicity against HL-60 cells with an IC(50) value of 4.9 microg/mL, induced apoptosis in HL-60 cells, and markedly activated caspase-3.
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