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. 2009 Aug;72(8):1399-404.
doi: 10.1021/np900168d.

Steroidal glycosides from Agave utahensis and their cytotoxic activity

Akihito Yokosuka  1 , Maki Jitsuno, Satoru Yui, Masatoshi Yamazaki, Yoshihiro Mimaki
Affiliations

Steroidal glycosides from Agave utahensis and their cytotoxic activity

Akihito Yokosuka et al. J Nat Prod. 2009 Aug.

Abstract

Eight new spirostanol saponins (1-8) and three new furostanol saponins (9-11) were isolated from the whole plants of Agave utahensis. The structures of 1-11 were determined by analysis of extensive spectroscopic data. The saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 showed cytotoxicity against HL-60 cells with an IC(50) value of 4.9 microg/mL, induced apoptosis in HL-60 cells, and markedly activated caspase-3.

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