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. 1990 Sep;4(3):171-9.
doi: 10.1016/0889-1591(90)90020-q.

Differential effects of beta-endorphin on cAMP levels in human peripheral blood mononuclear cells

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Differential effects of beta-endorphin on cAMP levels in human peripheral blood mononuclear cells

A Kavelaars et al. Brain Behav Immun. 1990 Sep.

Abstract

In the present paper we demonstrate that one of the early effects of the opioid peptide beta-endorphin on human peripheral blood mononuclear cells is the induction of a change in the intracellular cAMP level. However, the effect of beta-endorphin on cAMP levels is not uniform; increases as well as decreases in cAMP level are observed. It appears that beta-endorphin is a true modulator of intracellular cAMP level: the peptide will increase cAMP levels in cells with a low baseline level. In contrast, beta-endorphin tends to decrease cAMP levels is cells with a high cAMP concentration. Moreover, beta-endorphin modulates the rise in cAMP induced by beta-adrenergic activation. The effect of beta-endorphin on cAMP level correlates negatively with the magnitude of the change in cAMP level induced by beta-adrenergic activation.

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