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Comment
. 2009 Aug 4;16(2):81-2.
doi: 10.1016/j.ccr.2009.07.007.

Metastasis-promoting immunity: when T cells turn to the dark side

Drew Pardoll  1
Affiliations
Free article
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Metastasis-promoting immunity: when T cells turn to the dark side

Drew Pardoll. Cancer Cell. .
Free article

Abstract

While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.

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