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. 1990 Dec 24;537(1-2):328-32.
doi: 10.1016/0006-8993(90)90379-p.

Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate

M D Majewska  1 , J A Bell, E D London
Affiliations

Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate

M D Majewska et al. Brain Res. .

Abstract

Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [3H]glutamate and [3H]thienylcycohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter function of the NMDA receptor is abolished by oxidation.

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