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. 2010 Feb;13(2):289-96.
doi: 10.1017/S1368980009990802. Epub 2009 Aug 4.

Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania

Anirban Chatterjee  1 , Ronald J Bosch, Roland Kupka, David J Hunter, Gernard I Msamanga, Wafaie W Fawzi
Affiliations

Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania

Anirban Chatterjee et al. Public Health Nutr. 2010 Feb.

Abstract

Objective: Predictors and consequences of childhood anaemia in settings with high HIV prevalence are not well known. The aims of the present study were to identify maternal and child predictors of anaemia among children born to HIV-infected women and to study the association between childhood anaemia and mortality.

Design: Prospective cohort study. Maternal characteristics during pregnancy and Hb measurements at 3-month intervals from birth were available for children. Information was also collected on malaria and HIV infection in the children, who were followed up for survival status until 24 months after birth.

Setting: Dar es Salaam, Tanzania.

Subjects: The study sample consisted of 829 children born to HIV-positive women.

Results: Advanced maternal clinical HIV disease (relative risk (RR) for stage > or =2 v. stage 1: 1.31, 95 % CI 1.14, 1.51) and low CD4 cell counts during pregnancy (RR for <350 cells/mm3 v. > or =350 cells/mm3: 1.58, 95 % CI 1.05, 2.37) were associated with increased risk of anaemia among children. Birth weight <2500 g, preterm birth (<34 weeks), malaria parasitaemia and HIV infection in the children also increased the risk of anaemia. Fe-deficiency anaemia in children was an independent predictor of mortality in the first two years of life (hazard ratio 1.99, 95 % CI 1.06, 3.72).

Conclusions: Comprehensive care including highly active antiretroviral therapy to eligible HIV-infected women during pregnancy could reduce the burden of anaemia in children. Programmes for the prevention of mother-to-child transmission of HIV and antimalarial treatment to children could improve child survival in settings with high HIV prevalence.

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References

    1. Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ Comparative Risk Assessment Collaborating Group. Selected major risk factors and global and regional burden of disease. Lancet. 2002;360:1347–1360. - PubMed
    1. United Nations Administrative Committee on Coordination, Sub-committee on Nutrition. Fourth Report on the World Nutrition Situation: Nutrition Throughout the Life-cycle. Geneva: UN Press; 2000.
    1. Belperio PS, Rhew DC. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature. Am J Med. 2004;116(7A):27S–43S. - PubMed
    1. DeMaeyer E, Adiels-Tegman M. The prevalence of anemia in the world. World Health Stat Q. 1985;38:302–316. - PubMed
    1. Stoltzfus R, Mullany L, Black RE. Iron deficiency anemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, editors. Comparative Quantification of Health Risks: The Global and Regional Burden of Disease due to 25 Selected Major Risk Factors. Geneva: WHO; 2004. pp. 163–209.

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