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Review
. 2010 Mar 28;289(2):140-50.
doi: 10.1016/j.canlet.2009.07.004. Epub 2009 Aug 3.

Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis

Kwun Wah Wen  1 , Blossom Damania
Affiliations
Review

Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis

Kwun Wah Wen et al. Cancer Lett. .

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD.

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Conflict of interest statement

Disclosure Statement The authors have no conflict of interest to disclose.

Figures

Fig. 1
Fig. 1. The KSHV genomic open reading frames (ORFs)
The arrows represent individuals ORFs and the dots represent the KSHV encoded microRNAs. ORFs unique to KSHV are labeled K1 through K15 and are indicated by black arrows. Alternative names mentioned in this review for some of these unique KSHV genes are in parentheses. Additional ORFs discussed in this review paper are also labeled. The ORFs common to rhadinoviruses are indicated by dark gray arrows, ORFs common to other gammaherpesviruses (e.g. EBV) are indicated by light gray arrows, and ORFs common to most herpesviruses are indicated by white arrows. TR denotes terminal repeats. The numbers on demarcated lines specify the approximate genome positions in Kb.
See this image and copyright information in PMC

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