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. 2009 Jun;9(2):98-108.

Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey

Josephine Bwogi  1 , Fiona Braka, Issa Makumbi, Vinod Mishra, Barnabas Bakamutumaho, Miriam Nanyunja, Alex Opio, Robert Downing, Benon Biryahwaho, Rosamund F Lewis
Affiliations

Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey

Josephine Bwogi et al. Afr Health Sci. 2009 Jun.

Abstract

Background: Infant immunization against hepatitis B began in Uganda in 2002.

Objective: To determine the baseline prevalence of hepatitis B virus (HBV) infection and explore risk factors.

Methods: A hepatitis B prevalence study was nested in the 2005 national HIV/AIDS serobehavioural survey. Demographic characteristics and risk factors were explored by questionnaire. One third of blood specimens (n=5875) from adults aged 15 to 59 years were tested for hepatitis B core antibodies (HBcAb); positive specimens were tested for hepatitis B surface antigen (HBsAg).

Results: HBcAb was present in 52.3% (95% CI: 51.0-53.6) of adults, and HBsAg in 10.3% (9.5-11.1). By 15-19 years of age, 40.0% had been infected with HBV. Prevalence of both markers was significantly higher across northern Uganda, in rural areas, among the poor and least educated, and in uncircumcised men. Other independent predictors of infection were age, ethnic group, occupation, number of sex partners, and HIV and HSV-2 status.

Conclusion: Hepatitis B virus infection is highly endemic in Uganda, with transmission occurring in childhood and adulthood. More than 1.4 million adults are chronically infected and some communities disproportionately affected. The hepatitis B infant immunization programme should be sustained and catch-up vaccination considered for older children.

Keywords: HBcAb; HBsAg; HIV; Hepatitis B is highly endemic in Uganda; Uganda; circumcision; coinfection; hepatitis B; immunization; survey; vaccine.

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Figures

Figure 1
Figure 1
Proportion of adults with lifetime exposure (HBcAb) and current hepatitis B infection (HBsAg) by age, Uganda, 2005
Figure 2
Figure 2
Prevalence of current hepatitis B infection (HBsAg positive) by region, adults aged 15–59 years, Uganda, 2005
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References

    1. Kane MA. Global status of hepatitis B immunization. Lancet. 1996;348:696. - PubMed
    1. Kao JHCD. Global control of hepatitis B virus infection. Lancet Infect Dis. 2002;2:395–403. - PubMed
    1. World Health Organization. Department of Communicable Diseases Surveillance and Response, author. [29 June 2007];Hepatitis B. WHO/CDS/CSR/LYO/2002.2. www.who.int/csr/disease/hepa titis/HepatitisB_whocdscsrlyo2002_2.pdf.
    1. World Health Organization, author. Hepatitis B Vaccines. 79. Vol. 28. WER; 2004. [29 June 2007]. pp. 255–263. WHO position paper. www.who.int/wer/2004/en/wer7928.pdf.
    1. Margolis HS, Coleman PJ, Brown RE, Mast EE, Sheingold SH, Arevalo JA. Prevention of hepatitis B virus transmission by immunization; an economic analysis of current recommendations. JAMA. 1995;264:1201–1208. - PubMed

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