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. 2010 Jan;59(1):31-9.
doi: 10.1007/s00011-009-0067-x. Epub 2009 Aug 5.

Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis

Zhang Xiping  1 , Fu Jun, Zhang Jie, Yu Bingyan, Ma Jing, Zhu Wei, Ye Jing, Jia Penghui, Yuan Wenqin, Zhou Ninnin, He Jiao
Affiliations

Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis

Zhang Xiping et al. Inflamm Res. 2010 Jan.

Abstract

Objective: To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP).

Methods: Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed.

Results: In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05).

Conclusions: Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.

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