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Comment
. 2009 Aug;10(2):80-1.
doi: 10.1016/j.cmet.2009.07.007.

Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways

Tracey A Rouault  1 , Wing-Hang Tong
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Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways

Tracey A Rouault et al. Cell Metab. 2009 Aug.
Free article

Abstract

A large-scale computational and genetic analysis study by Nilsson et al. (2009) has identified five genes that coexpress with heme biosynthetic enzymes and are required for normal heme synthesis. Several are implicated in iron-sulfur cluster biogenesis, and malfunction of these genes may repress heme synthesis by activating the IRE/IRP posttranscriptional regulatory system.

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