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. 2009 Nov;16(11):1091-6.
doi: 10.1177/1933719109341843. Epub 2009 Aug 5.

Relationship between prepregnancy and early pregnancy uterine blood flow and resistance index

Sarah A Hale  1 , Adrienne Schonberg, Gary J Badger, Ira M Bernstein
Affiliations

Relationship between prepregnancy and early pregnancy uterine blood flow and resistance index

Sarah A Hale et al. Reprod Sci. 2009 Nov.

Abstract

We evaluated the relationship between prepregnancy and early pregnancy uterine blood flow (UBF) and resistance index (RI). Nineteen nulliparous participants were studied during cycle day 8 + 4, and early pregnancy (13.4 + 1.6 weeks). Color Doppler ultrasound of both uterine arteries and maternal heart was performed to calculate uterine RI, volumetric UBF, and cardiac output (CO), respectively. We observed a strong negative association of uterine RI with prepregnancy UBF (r = -.82, P < .001) that weakened, but remained significant in early pregnancy (r =-.48, P = .04). Prepregnancy uterine index (UBF/CO) was significantly associated with early pregnancy uterine index; r = .48, P = .04). There was also a trend associating prepregnancy and early pregnancy volumetric UBF (r = .44, P = .068). Prepregnancy UBF may be a determinant of early pregnancy UBF and UBF may have independent value as a predictor of adverse pregnancy outcome.

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Figures

Figure 1
Figure 1
A: Mean prepregnancy resistance index is negatively and significantly correlated to total prepregnancy uterine blood flow (r = −.82, p < 0.001) and B: mean early pregnancy RI is negatively and significantly correlated with total early pregnancy uterine blood flow though this association in early pregnancy is less than in prepregnancy (r = − .48, p = 0.03).
Figure 2
Figure 2
Early pregnancy uterine index is positively and significantly correlated with prepregnancy uterine index (partial r = .48, p = 0.04).
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