Increased efficacy of ganciclovir and foscarnet inhibition of cytomegalovirus replication in vitro by encapsulation in liposomes
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- PMID: 1965866
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Increased efficacy of ganciclovir and foscarnet inhibition of cytomegalovirus replication in vitro by encapsulation in liposomes
Scand J Infect Dis Suppl.
1990.
Abstract
The antiviral effect of ganciclovir and foscarnet encapsulated in liposomes was studied against cytomegalovirus in human embryonic lung fibroblast cells. Substantially greater activity (3.5-fold and 38-fold respectively) in terms of inhibition of virus replication intracellularly was found compared to that seen with non-encapsulated antiviral agents, and liposome encapsulation did not result in increased cytotoxicity.
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