[Granulocyte beta-adrenoceptor density increased with methylprednisolone in patients receiving dopamine infusion]

Abstract

Methylprednisolone (MP) is frequently used in shock states, its antishock mechanisms, however, have not been clarified. Effect of MP 10 mg.kg-1 on granulocyte beta-adrenoceptor density was studied in two patients who required dopamine infusion postoperatively. The granulocyte beta-adrenoceptor density was calculated from the binding of [3H] dihydroalprenolol. Arterial blood pressure and cardiac output increased 1 hr after MP administrations. Beta-adrenoceptor densities were low in both cases prior to the administration of MP (16.1 and 24.6 fmol.mg-1 protein), which increased 11 hr after MP (31.2 and 35.8 fmol.mg-1 protein, respectively). The effects of MP to improve status of cardiovascular system in patients receiving catecholamine-infusion may be associated with the increase in the density of myocardial "down-regulated" beta-adrenoceptor.