Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2009 Oct;50(4):942-945.e2.
doi: 10.1016/j.jvs.2009.04.076. Epub 2009 Aug 5.

Claudication: exercise vs endoluminal revascularization (CLEVER) study update

Timothy P Murphy  1 , Alan T Hirsch, Donald E Cutlip, Judith G Regensteiner, Anthony J Comerota, Emile Mohler, David J Cohen, Joseph Massaro; CLEVER Investigators
Affiliations
Randomized Controlled Trial

Claudication: exercise vs endoluminal revascularization (CLEVER) study update

Timothy P Murphy et al. J Vasc Surg. 2009 Oct.

Abstract

The Claudication: Exercise vs Endoluminal Revascularization (CLEVER) Study is a prospective multicenter randomized clinical trial designed to compare the relative clinical and cost-effectiveness of invasive revascularization with stents to supervised exercise rehabilitation in a cohort with moderate to severe claudication due to aortoiliac insufficiency. The study is currently enrolling at twenty-eight sites in the US and Canada. Enrollment of 217 participants is planned, with data collected at baseline, six months, and 18 months. The primary study endpoint is maximum walking duration (MWD) on a graded treadmill test; secondary endpoints include community-based walking, markers of cardiovascular disease risk (body mass index, waist circumference, blood pressure, lipid profile, glucose tolerance, and plasma fibrinogen), health-related quality of life, and cost effectiveness. There are currently sixty randomized participants; recruitment is projected to end in July 2010 and final study results reported in June 2012.

PubMed Disclaimer

Comment in

  • Invited commentary.
    Stoner M. Stoner M. J Vasc Surg. 2009 Oct;50(4):945. doi: 10.1016/j.jvs.2009.05.014. J Vasc Surg. 2009. PMID: 19786243 No abstract available.

References

    1. Murphy TP, Hirsch AT, Ricotta JJ, Cutlip DE, Mohler E, Regensteiner JG, et al. The Claudication: Exercise Vs. Endoluminal Revascularization (CLEVER) study: rationale and methods. J Vasc Surg. 2008;47:1356–63. - PMC - PubMed

    2. Notes: CORPORATE NAME: CLEVER Steering Committee

    1. Beebe HG, Dawson DL, Cutler BS, Herd JA, Strandness DE, Jr, Bortey EB, et al. A new pharmacological treatment for intermittent claudication: results of a randomized, multicenter trial. Arch Intern Med. 1999;159:2041–50. - PubMed
    1. Pocock SJ, Elbourne DR. Randomized trials or observational tribulations? N Engl J Med. 2000;342:1907–9. - PubMed
    1. Pear R. US to Compare Medical Treatments. New York Times, Money & Policy; [February 15, 2009]. at http://www.nytimes.com/2009/02/16/health/policy/16health.html.) Abstract.
    1. Hirsch AT, Hartman L, Town RJ, Virnig BA. National health care costs of peripheral arterial disease in the Medicare population. Vasc Med. 2008;13:209–15. - PubMed

Publication types