doi: 10.1016/j.bmcl.2009.07.092.
Epub 2009 Jul 23.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors
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- PMID: 19660943
- DOI: 10.1016/j.bmcl.2009.07.092
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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors
Bioorg Med Chem Lett.
.
Erratum in
- Bioorg Med Chem Lett. 2010 Dec 15;20(24):7553. Bard, Frédérique [added]; Yednock, Ted A [added]
Abstract
In this Letter, we report our strategy to design potent and metabolically stable gamma-secretase inhibitors that are efficacious in reducing the cortical Abetax-40 levels in FVB mice via a single PO dose.
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