Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Sep 1;19(17):4920-3.
doi: 10.1016/j.bmcl.2009.07.092. Epub 2009 Jul 23.

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors

Anh P Truong  1 , Danielle L Aubele, Gary D Probst, Martin L Neitzel, Chris M Semko, Simeon Bowers, Darren Dressen, Roy K Hom, Andrei W Konradi, Hing L Sham, Albert W Garofalo, Pamela S Keim, Jing Wu, Michael S Dappen, Karina Wong, Erich Goldbach, Kevin P Quinn, John-Michael Sauer, Elizabeth F Brigham, William Wallace, Lan Nguyen, Susanna S Hemphill, Michael P Bova, Frédérique Bard, Ted A Yednock, Guriqbal Basi
Affiliations

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors

Anh P Truong et al. Bioorg Med Chem Lett. .

Erratum in

  • Bioorg Med Chem Lett. 2010 Dec 15;20(24):7553. Bard, Frédérique [added]; Yednock, Ted A [added]

Abstract

In this Letter, we report our strategy to design potent and metabolically stable gamma-secretase inhibitors that are efficacious in reducing the cortical Abetax-40 levels in FVB mice via a single PO dose.

PubMed Disclaimer

MeSH terms

LinkOut - more resources