[Application of self-assembling peptide nanofiber scaffold in nerve tissue engineering]

Abstract

Objective: To review the fundamental research and the experimental study in the nerve tissue engineering of self-assembling peptide nanofiber scaffold (SAPNS).

Methods: The literature concerning basic and experimental studies on SAPNS in the nerve tissue engineering was extensively reviewed.

Results: SAPNS can promote the neural stem cell adhesion, proliferation, differentiation and neuron axon outward growth and extension, promote extracellular matrix synthesis and inhibit glial cell adhesion and differentiation, and simulate the environment of a cell in the body.

Conclusion: SAPNS is an ideal matrix material and provides a new way for the repair of nerve tissue injury.