Role of cytoreductive nephrectomy in renal cell carcinoma
- PMID: 19663735
- DOI: 10.2217/fon.09.52
Role of cytoreductive nephrectomy in renal cell carcinoma
Abstract
Cytoreductive nephrectomy prior to cytokine therapy has a well-established role in the treatment of appropriately selected patients with metastatic renal cell carcinoma (RCC). Recent use of novel molecular targeted agents in the management of metastatic RCC has challenged the current dogma of treatment with regards to the necessity, patient selection for and timing of cytoreductive nephrectomy. Current evidence suggests that cytoreductive nephrectomy still plays an integral part in the multimodal paradigm of management for metastatic RCC. This review highlights the role of cytoreductive nephrectomy, and discusses controversial issues surrounding cytoreductive nephrectomy in the treatment of metastatic RCC, in the context of immunotherapy and also in the new era of targeted therapy. It also gives updates on the changing concepts of surgical approaches to cytoreductive nephrectomy in metastatic RCC.
Similar articles
-
Cytoreductive nephrectomy in metastatic renal cell carcinoma.Curr Opin Urol. 2008 Sep;18(5):474-80. doi: 10.1097/MOU.0b013e32830a4f21. Curr Opin Urol. 2008. PMID: 18670270 Review.
-
Cytoreductive nephrectomy in metastatic renal cell carcinoma: the evolving role of surgery in the era of molecular targeted therapy.Curr Opin Support Palliat Care. 2009 Sep;3(3):157-65. doi: 10.1097/SPC.0b013e32832e466b. Curr Opin Support Palliat Care. 2009. PMID: 19528804 Review.
-
[Role of surgery (cytoreductive nephrectomy and metastasectomy) in the management of metastatic renal cell carcinoma: a literature review].Prog Urol. 2010 Dec;20(13):1175-83. doi: 10.1016/j.purol.2010.06.001. Epub 2010 Jul 6. Prog Urol. 2010. PMID: 21130395 Review. French.
-
Cytoreductive nephrectomy for metastatic renal cell carcinoma: is it still imperative in the era of targeted therapy?Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):693s-696s. doi: 10.1158/1078-0432.CCR-06-1916. Clin Cancer Res. 2007. PMID: 17255295 Review.
-
Is cytoreductive nephrectomy relevant in the immunotherapy era?Curr Opin Urol. 2019 Sep;29(5):526-530. doi: 10.1097/MOU.0000000000000659. Curr Opin Urol. 2019. PMID: 31305273 Review.
Cited by
-
Role of cytoreductive nephrectomy in the era of targeted therapy for renal cell carcinoma.Curr Urol Rep. 2012 Feb;13(1):38-46. doi: 10.1007/s11934-011-0225-x. Curr Urol Rep. 2012. PMID: 22105577 Review.
-
Cytoreductive Nephrectomy and Metastatic Renal Cell Carcinoma: State of the Art and Future Perspectives.Medicina (Kaunas). 2023 Apr 15;59(4):767. doi: 10.3390/medicina59040767. Medicina (Kaunas). 2023. PMID: 37109725 Free PMC article. Review.
-
Treatment of metastatic renal cell carcinoma.Nat Rev Urol. 2010 Jun;7(6):327-38. doi: 10.1038/nrurol.2010.57. Epub 2010 May 11. Nat Rev Urol. 2010. PMID: 20458330 Review.
-
Surgical challenges in the treatment of a giant renal cell carcinoma with atypical presentation: A case report.Int J Surg Case Rep. 2016;24:63-6. doi: 10.1016/j.ijscr.2016.05.010. Epub 2016 May 9. Int J Surg Case Rep. 2016. PMID: 27183332 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical