Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2010 Jan-Feb;34(1):101-9.
doi: 10.5993/ajhb.34.1.12.

A multicenter phase 3 trial of lobeline sulfate for smoking cessation

Elbert D Glover  1 , Jessica M Rath, Eva Sharma, Penny N Glover, Molly Laflin, Philip Tonnesen, Lawrence Repsher, John Quiring
Affiliations
Clinical Trial

A multicenter phase 3 trial of lobeline sulfate for smoking cessation

Elbert D Glover et al. Am J Health Behav. 2010 Jan-Feb.

Abstract

Objective: To evaluate the safety and efficacy of sublingual lobeline sulfate for smoking cessation.

Methods: A multicenter (3 sites), double-blind, parallel, placebo-controlled, phase 3 smoking cessation trial of sublingual formulation of lobeline sulfate. A total of 750 smokers (250 per site) were randomized to either treatment (lobeline sulfate) or placebo with individual smoking cessation counseling lasting up to approximately 10 minutes.

Results: Efficacy revealed no statistical significance (P = 0.62) for lobeline sulfate as a smoking cessation aid.

Conclusion: Sublingual formulation of lobeline sulfate does not appear to be an effective smoking cessation aid.

PubMed Disclaimer

Publication types

LinkOut - more resources