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Multicenter Study
. 2009 Oct;147(1):125-8.
doi: 10.1111/j.1365-2141.2009.07844.x. Epub 2009 Aug 5.

International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia

Thomas Lehrnbecher  1 , Marie-Chantal Ethier, Theoklis Zaoutis, Ursula Creutzig, Alan Gamis, Dirk Reinhardt, Richard Aplenc, Lillian Sung
Affiliations
Multicenter Study

International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia

Thomas Lehrnbecher et al. Br J Haematol. 2009 Oct.

Abstract

This study described infection-related supportive care practices amongst centres participating in two large paediatric acute myeloid leukaemia (AML) cooperative groups, Children's Oncology Group (COG) and Berlin-Frankfurt-Muenster (BFM). We surveyed 216 COG and 55 BFM institutions. The overall survey response rate was 83.8%. Antibacterial prophylaxis was more common among BFM (15/46, 32.6%) compared to COG (24/180, 13.3%, P < 0.0001) institutions. Antifungal prophylaxis also was more common among BFM (42/46, 91.3%) compared to COG (137/178, 77.0%, P = 0.03). There were systematic differences in infection-related supportive care practices. This information may be used to encourage harmonization of supportive care practices and future randomized trials.

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