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Review
. 2009 Aug;36(4):358-71.
doi: 10.1053/j.seminoncol.2009.06.008.

Other targetable sarcomas

Veridiana Pires de Camargo  1 , Matt van de Rijn, Roberta Maestro, Enrique de Alava, Juan Madoz-Gúrpide, Silvana Pilotti, Margaret von Mehren, Florence Pedeutour, Robert G Maki, Piotr Rutkowski, David M Thomas
Affiliations
Review

Other targetable sarcomas

Veridiana Pires de Camargo et al. Semin Oncol. 2009 Aug.

Erratum in

  • Semin Oncol. 2009 Oct;36(5):489. Maestro, Roberta [added]

Abstract

Despite complex genetics, aneuploid tumors like dedifferentiated liposarcoma have specific and reproducible chromosomal changes such as amplification of HDM2 and CDK4 that represent potential targets for systemic therapy. In addition, there are cancer cell survival pathways that may not be the target of chromosomal translocations or mutations that are still estimable targets for new systemic therapeutics, be it pathways involved in angiogenesis or apoptosis. In this review, we examine target selection for specific sarcoma subtypes, and demonstrate with a few examples new techniques being used to delineate novel therapeutic inroads for patients with sarcoma.

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