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. 2009 Sep 15;19(18):5392-6.
doi: 10.1016/j.bmcl.2009.07.114. Epub 2009 Jul 28.

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

Daniel Guay  1 , Christian Beaulieu, Jean-Francois Truchon, T Jagadeeswar Reddy, Robert Zamboni, Christopher I Bayly, Nathalie Methot, Joel Rubin, Diane Ethier, M David Percival
Affiliations

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

Daniel Guay et al. Bioorg Med Chem Lett. .

Erratum in

  • Bioorg Med Chem Lett. 2009 Nov 15;19(22):6481
  • Bioorg Med Chem Lett. 2010 Feb 15;20(4):1463. Truchon, Jean-Francois [added]; Bayly, Christopher I [added]

Abstract

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.

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