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Comment
. 2009 Aug 7;138(3):423-4.
doi: 10.1016/j.cell.2009.07.025.

MicroRNAs and parallel stem cell lives

Peter B Dirks  1
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Free article
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MicroRNAs and parallel stem cell lives

Peter B Dirks. Cell. .
Free article

Abstract

A new study by Shimono et al. (2009) demonstrates that certain microRNAs that regulate the self-renewal factor BMI1 are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-initiating cells. These findings have important implications for the regulation of self-renewal and differentiation by microRNAs and suggest new ways of targeting cancer stem cells.

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