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doi: 10.1016/j.cell.2009.07.022.
Alpha cells beget beta cells
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- PMID: 19665963
- DOI: 10.1016/j.cell.2009.07.022
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Alpha cells beget beta cells
Cell.
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Free article
Abstract
Understanding the origins of insulin-producing beta cells of the pancreas could lead to new treatments for diabetes. Collombat et al. (2009) now show that in response to injury, a population of pancreatic progenitor cells can give rise to glucagon-expressing alpha cells that then transdifferentiate into beta cells.
Comment on
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The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.Cell. 2009 Aug 7;138(3):449-62. doi: 10.1016/j.cell.2009.05.035. Cell. 2009. PMID: 19665969 Free PMC article.
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