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Comment
. 2009 Aug 7;138(3):428-30.
doi: 10.1016/j.cell.2009.07.021.

DNA makes RNA makes innate immunity

Luke A J O'Neill  1
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DNA makes RNA makes innate immunity

Luke A J O'Neill. Cell. .
Free article

Abstract

Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.

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