doi: 10.1097/00001756-199009000-00020.
The effect of intracerebroventricular administration of baclofen on food intake in rats
Affiliations
- PMID: 1966600
- DOI: 10.1097/00001756-199009000-00020
Item in Clipboard
The effect of intracerebroventricular administration of baclofen on food intake in rats
Neuroreport.
1990 Sep.
Abstract
In the present study the effects of intracerebroventricular (ICV) administration of baclofen (0.1-5.0 nmol) was investigated on food intake in non-fasted rats. Baclofen (1.0, 2.5 and 5.0 nmol) increased food consumption in a dose-related manner during the first 15-30 min after administration. The effects of baclofen (5.0 nmol) on feeding were prevented by pretreating the rats with the specific GABA-B receptor antagonist phaclofen (40 nmol, ICV). These results suggest that baclofen increases food intake in rats by an action at central GABA-B receptors.
Similar articles
-
Effect of intracerebroventricular administration of the GABAB-receptor agonist baclofen on operant feeding in satiated pigs.Br J Pharmacol. 1990 Nov;101(3):559-62. doi: 10.1111/j.1476-5381.1990.tb14120.x. Br J Pharmacol. 1990. PMID: 1963798 Free PMC article.
-
The effect of systemic administration of baclofen on food intake in rats.Neuropharmacology. 1992 Jan;31(1):39-42. doi: 10.1016/0028-3908(92)90158-l. Neuropharmacology. 1992. PMID: 1311808
-
Phaclofen-sensitive GABA-B receptors do not mediate excitatory effects of baclofen on gastric secretion.Pharmacology. 1991;42(3):128-34. doi: 10.1159/000138789. Pharmacology. 1991. PMID: 1647534
-
Phaclofen antagonizes the antinociceptive but not the sedative effects of (-)-baclofen.Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(4):597-607. doi: 10.1016/0278-5846(90)90011-5. Prog Neuropsychopharmacol Biol Psychiatry. 1990. PMID: 2173023
-
The effects of intraperitoneal and intracerebroventricular administration of the GABAB receptor antagonist CGP 35348 on food intake in rats.Eur J Pharmacol. 2004 Oct 25;503(1-3):89-93. doi: 10.1016/j.ejphar.2004.09.002. Eur J Pharmacol. 2004. PMID: 15496301
Cited by
-
Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks.J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 Nov;198(11):827-32. doi: 10.1007/s00359-012-0753-y. Epub 2012 Sep 13. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012. PMID: 22972230
-
2-Naphthalenesulphanyl-L-aspartyl-2-(phenethyl) amide (2-NAP) and food intake in rats: evidence that endogenous peripheral CCK does not play a major role as a satiety factor.Br J Pharmacol. 1995 Nov;116(5):2371-4. doi: 10.1111/j.1476-5381.1995.tb15082.x. Br J Pharmacol. 1995. PMID: 8581271 Free PMC article.
-
Baclofen reduces fat intake under binge-type conditions.Physiol Behav. 2005 Sep 15;86(1-2):176-84. doi: 10.1016/j.physbeh.2005.07.020. Physiol Behav. 2005. PMID: 16140347 Free PMC article.
-
Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone.Cell Metab. 2018 Jul 3;28(1):55-68.e7. doi: 10.1016/j.cmet.2018.05.001. Epub 2018 May 31. Cell Metab. 2018. PMID: 29861386 Free PMC article.
-
Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats.Pharmacol Biochem Behav. 2006 Jun;84(2):197-206. doi: 10.1016/j.pbb.2006.04.015. Epub 2006 Jun 19. Pharmacol Biochem Behav. 2006. PMID: 16782181 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources