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. 1990 Sep;1(1):73-6.
doi: 10.1097/00001756-199009000-00020.

The effect of intracerebroventricular administration of baclofen on food intake in rats

I S Ebenezer  1
Affiliations

The effect of intracerebroventricular administration of baclofen on food intake in rats

I S Ebenezer. Neuroreport. 1990 Sep.

Abstract

In the present study the effects of intracerebroventricular (ICV) administration of baclofen (0.1-5.0 nmol) was investigated on food intake in non-fasted rats. Baclofen (1.0, 2.5 and 5.0 nmol) increased food consumption in a dose-related manner during the first 15-30 min after administration. The effects of baclofen (5.0 nmol) on feeding were prevented by pretreating the rats with the specific GABA-B receptor antagonist phaclofen (40 nmol, ICV). These results suggest that baclofen increases food intake in rats by an action at central GABA-B receptors.

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