Review
doi: 10.1016/j.molbiopara.2009.08.001.
Epub 2009 Aug 8.
Post-translational modifications in Plasmodium: more than you think!
Affiliations
- PMID: 19666057
- DOI: 10.1016/j.molbiopara.2009.08.001
Item in Clipboard
Review
Post-translational modifications in Plasmodium: more than you think!
Mol Biochem Parasitol.
2009 Dec.
Abstract
Recent evidences indicate that transcription in Plasmodium may be hard-wired and rigid, deviating from the classical model of transcriptional gene regulation. Thus, it is important that other regulatory pathways be investigated as a comprehensive effort to curb the deadly malarial parasite. Research in post-translational modifications in Plasmodium is an emerging field that may provide new venues for drug discovery and potential new insights into how parasitic protozoans regulate their life cycle. Here, we discuss the recent findings of post-translational modifications in Plasmodium.
Similar articles
-
The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation.Mol Biochem Parasitol. 2016 Jul;208(1):2-15. doi: 10.1016/j.molbiopara.2016.05.006. Epub 2016 May 17. Mol Biochem Parasitol. 2016. PMID: 27211241 Review.
-
Post-translational modifications influence transcription factor activity: a view from the ETS superfamily.Bioessays. 2005 Mar;27(3):285-98. doi: 10.1002/bies.20198. Bioessays. 2005. PMID: 15714552 Review.
-
Regulation of SRC family coactivators by post-translational modifications.Cell Signal. 2007 Jun;19(6):1101-12. doi: 10.1016/j.cellsig.2007.02.002. Epub 2007 Feb 20. Cell Signal. 2007. PMID: 17368849 Review.
-
Plasmodium pre-erythrocytic stages: what's new?Trends Parasitol. 2008 Dec;24(12):564-9. doi: 10.1016/j.pt.2008.08.009. Epub 2008 Oct 17. Trends Parasitol. 2008. PMID: 18929511 Review.
-
Protein translation in Plasmodium parasites.Trends Parasitol. 2011 Oct;27(10):467-76. doi: 10.1016/j.pt.2011.05.005. Epub 2011 Jul 7. Trends Parasitol. 2011. PMID: 21741312 Review.
Cited by
-
PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3956-61. doi: 10.1073/pnas.1121567109. Epub 2012 Feb 21. Proc Natl Acad Sci U S A. 2012. PMID: 22355110 Free PMC article.
-
Distinct patterns of blood-stage parasite antigens detected by plasma IgG subclasses from individuals with different level of exposure to Plasmodium falciparum infections.Malar J. 2010 Oct 26;9:296. doi: 10.1186/1475-2875-9-296. Malar J. 2010. PMID: 20977761 Free PMC article.
-
Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle.Int J Mol Sci. 2024 Jun 2;25(11):6145. doi: 10.3390/ijms25116145. Int J Mol Sci. 2024. PMID: 38892332 Free PMC article. Review.
-
Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi.PLoS One. 2017 Jun 12;12(6):e0176533. doi: 10.1371/journal.pone.0176533. eCollection 2017. PLoS One. 2017. PMID: 28604779 Free PMC article.
-
Multiple dimensions of epigenetic gene regulation in the malaria parasite Plasmodium falciparum: gene regulation via histone modifications, nucleosome positioning and nuclear architecture in P. falciparum.Bioessays. 2015 Feb;37(2):182-94. doi: 10.1002/bies.201400145. Epub 2014 Nov 13. Bioessays. 2015. PMID: 25394267 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
