Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus
- PMID: 19666089
- DOI: 10.1016/j.toxlet.2009.07.028
Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus
Abstract
For the purpose of investigating the role of physical exercise in developmental seizure-induced cognitive deficit, hippocampal mossy fiber sprouting and related gene expression, a seizure was induced by penicillin every other day in Sprague-Dawley rats from postnatal day 24 (P24). The authors assigned ten rats each randomly into the control group (CONT1), the control plus exercise group (CONT2), the seizure group (EXP1) and the seizure plus exercise group (EXP2). Morris water maze test was used respectively during P39-P45 and P61-P66. Treadmill exercise was performed daily by CONT2 and EXP2 rats during P49-P54. On P66, mossy fiber sprouting and gene expression in hippocampus were assessed by Timm staining and real-time RT-PCR. EXP2 rats performed better than EXP1 rats in the second water maze navigation test. In the entire two spatial probe tests, both EXP1 and EXP2 rats performed worse than the two control rats. Physical exercise remarkably reduced the aberrant mossy fiber sprouting in the supragranular region of dentate gyrus and CA3 subfield of hippocampus. Both EXP1 and EXP2 rats had a higher amount of glutamate receptor 1 (GluR1) and lower amount of the ratio of GluR2/GluR1 in hippocampus when compared with CONT rats. In addition, there was long-term enhancement of both gamma-aminobutyric acid receptor A-alpha3 (GABA-Aalpha3) and cholecystokinin (CCK) of EXP2 rats compared with the other three groups. These results showed that physical exercise improved learning capacity by modulating hippocampal regenerative sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus.
Similar articles
-
Effects of penicillin-induced developmental epilepticus on hippocampal regenerative sprouting, related gene expression and cognitive deficits in rats.Toxicol Lett. 2009 Jul 24;188(2):161-6. doi: 10.1016/j.toxlet.2009.04.002. Epub 2009 Apr 10. Toxicol Lett. 2009. PMID: 19446251
-
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.Toxicol Lett. 2013 Feb 27;217(2):162-9. doi: 10.1016/j.toxlet.2012.12.010. Epub 2012 Dec 21. Toxicol Lett. 2013. PMID: 23266720
-
Hippocampal mossy fiber sprouting induced by forced and voluntary physical exercise.Physiol Behav. 2010 Sep 1;101(2):302-8. doi: 10.1016/j.physbeh.2010.05.012. Epub 2010 Jun 1. Physiol Behav. 2010. PMID: 20515703
-
Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system.Prog Brain Res. 2007;163:541-63. doi: 10.1016/S0079-6123(07)63029-5. Prog Brain Res. 2007. PMID: 17765737 Review.
-
Seizure-induced molecular changes, sprouting and synaptogenesis of hippocampal mossy fibers.Epilepsy Res Suppl. 1996;12:355-63. Epilepsy Res Suppl. 1996. PMID: 9302535 Review. No abstract available.
Cited by
-
Sex-dependent and independent effects of long-term voluntary wheel running on Bdnf mRNA and protein expression.Physiol Behav. 2016 Mar 15;156:8-15. doi: 10.1016/j.physbeh.2015.12.026. Epub 2016 Jan 2. Physiol Behav. 2016. PMID: 26752611 Free PMC article.
-
Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of cathepsin B.Neurochem Res. 2012 Jan;37(1):31-9. doi: 10.1007/s11064-011-0578-z. Epub 2011 Aug 13. Neurochem Res. 2012. PMID: 21842268
-
Animal models of epilepsy: use and limitations.Neuropsychiatr Dis Treat. 2014 Sep 9;10:1693-705. doi: 10.2147/NDT.S50371. eCollection 2014. Neuropsychiatr Dis Treat. 2014. PMID: 25228809 Free PMC article. Review.
-
Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus.PLoS One. 2015 Aug 5;10(8):e0132676. doi: 10.1371/journal.pone.0132676. eCollection 2015. PLoS One. 2015. PMID: 26244549 Free PMC article.
-
[Effects of embryonic lead exposure on motor function and balance ability in offspring rats and possible mechanisms].Zhongguo Dang Dai Er Ke Za Zhi. 2017 Mar;19(3):361-367. doi: 10.7499/j.issn.1008-8830.2017.03.022. Zhongguo Dang Dai Er Ke Za Zhi. 2017. PMID: 28302213 Free PMC article. Chinese.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous