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Comment
. 2009 Aug 11;106(32):13149-50.
doi: 10.1073/pnas.0906989106. Epub 2009 Aug 5.

A new direction for titin pulling

Ronald S Rock  1
Affiliations
Comment

A new direction for titin pulling

Ronald S Rock. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
A highly simplified cartoon of the 2:1 titin–telethonin complex illustrating the directional bond. Two titin fragments (green and blue) consisting of the Z1Z2 domains are shown with a bridging telethonin molecule (red). When pulled from the C-terminal ends of the Z2 domains, as experienced in the cell, the complex can support high forces. However, when pulled from the N-terminal ends of the Z1 domains, the complex dissociates at significantly lower forces. Note that these ends of the Z1 domains do not directly interact with telethonin.
See this image and copyright information in PMC

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References

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