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. 2009 Aug;27(8):732-3.
doi: 10.1038/nbt0809-732.

Next-generation quantum dots

Andrew M Smith, Shuming Nie

Next-generation quantum dots

Andrew M Smith et al. Nat Biotechnol. 2009 Aug.

Abstract

Quantum dots that are small and non-blinking offer new opportunities for dynamic single-molecule imaging in live cells.

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Figures

Figure 1
Figure 1
Comparison of current and next-generation quantum dots. (a) Current quantum dots are elongated core-shell nanocrystals coated with a thick organic bilayer and are limited by signal intermittency (blinking), a bulky size and undefined valency (depicted here with tetrameric streptavidin conjugates). (b) Through nanocrystal engineering, Wang et al. produced smaller quantum dots that do not blink owing to a gradient alloy structure. In addition, these quantum dots can be coated with a compact monolayer of ligands and conjugated with a defined biomolecular valency (illustrated here with monovalent streptavidin).
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