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. 2008 Mar;2(1):153-7.
doi: 10.2147/opth.s2281.

False negative results in glaucoma detection with Heidelberg Retina Tomograph II

Catherine Deghislage  1 , Lidwine Van Malderen, Thierry G Zeyen
Affiliations
Free PMC article

False negative results in glaucoma detection with Heidelberg Retina Tomograph II

Catherine Deghislage et al. Clin Ophthalmol. 2008 Mar.
Free PMC article

Abstract

Purpose: To evaluate the rate of false negative results with the Heidelberg Retina Tomograph (HRT II) in a glaucoma practice.

Design: Cross-sectional study.

Methods: We analyzed the HRTs taken between October 2002 and October 2003 in our glaucoma clinic, and selected the patients who had a good quality image (SD < 40 mu) with a normal Moorfield's Regression Analysis (MRA). A masked independent observer classified those patients as normal, glaucoma suspect, or glaucomatous on the basis of optic disc stereo photos (ODP) and at least 2 consecutive reliable automated perimetries. The diagnosis of glaucoma was based on a glaucomatous optic disc with a congruent, reproducible visual field defect.

Results: Four hundred and fifty patients who had undergone an HRT examination were analyzed. One hundred and nine patients had an HRT classified as normal on the MRA, and a good quality image. Fifteen of those 109 patients (13.7%) were classified as glaucomatous on the basis of an abnormal ODP with corresponding visual field defect. Seven (6.4%) patients were classified as glaucoma suspect.

Conclusion: Fourteen percent of glaucoma patients with glaucoma remained undetected with the HRT II Moorfield's regression analysis as a sole means to detect glaucoma.

Keywords: Heidelberg Retina Tomograph II; false negative results; glaucoma detection.

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Figures

Figure 1
Figure 1
Results.
Figure 2
Figure 2
Example of false negative result. HRT with normal MRA analysis, but glaucomatous cupping on ODP with corresponding visual field defect on automated perimetry. Abbreviations: HRT, Heidelberg Retina Tomography; MRA, Moorfields regression analysis; ODP, Optic Disc Photograph.
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References

    1. Asmann P, Heijl A. Glaucoma hemifield test: Automated visual field evaluation. Arch Ophthalmol. 1992;110:812–19. - PubMed
    1. Brusini P, Salvetat ML, Zeppieri M, et al. Frequency doubling technology perimetry with the Humphrey Matrix 30–2 test. J Glaucoma. 2006;15:77–83. - PubMed
    1. [EGS] European Glaucoma Society. Terminology and Guidelines for Glaucoma. (2nd ed) 2004 [online]. Accessed on 9 January, 2007. URL: http://www.eugs.org/fullbook.asp.
    1. [EGP] European Glaucoma Prevention Study Group. Reproducibility of evaluation of optic disc change for glaucoma with the stereo optic disc photographs. Ophthalmology. 2003;110:340–4. - PubMed
    1. [EGP] European Glaucoma Prevention Study Group. Results of the European Glaucoma Prevention Study. Ophthalmology. 2005;112:366–375. - PubMed