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. 2008 Jun;2(2):196-201.
doi: 10.1007/s12072-008-9058-1. Epub 2008 Feb 28.

A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)

Yin-Mei Lee  1 , Dede S Sutedja, Chun-Tao Wai, Yock-Young Dan, Myat-Oo Aung, Lei Zhou, Chee-Leong Cheng, Aileen Wee, Seng-Gee Lim
Affiliations

A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)

Yin-Mei Lee et al. Hepatol Int. 2008 Jun.

Abstract

Purpose: Tumor necrosis factor-alpha (TNF-alpha) is implicated in non-alcoholic steatohepatitis (NASH). Pentoxifylline inhibits TNF-alpha. We wanted to evaluate the efficacy of Pentoxifylline on NASH patients.

Methods: Patients with biopsy proven NASH and persistently elevated alanine aminotransferase (ALT) greater than 1.5 times the upper limit of normal were randomized to 3 months of treatment with a step 1 American Heart Association diet and daily exercise with Pentoxifylline or placebo. Liver function tests, serum lipids and TNF-alpha, Interleukin 6 (IL-6), and plasma hyaluronic acid were measured at baseline, at weeks 6 and 12. Categorical data were analyzed by Fisher's exact test while independent sample t-test and Mann-Whitney test were used for continuous data.

Results: Eleven patients were randomized into the Pentoxifylline and nine to the placebo group. After 3 months of treatment body mass index (BMI), ALT and aspartate aminotransferase (AST) decreased significantly in both groups. There was no difference between the two groups in reduction of BMI (P = 0.897). There was significantly greater reduction in AST in the Pentoxifylline group (P = 0.038). There was a trend toward lower ALT level (P = 0.065) in the Pentoxifylline group. TNF-alpha and IL-6 decreased significantly in both groups after treatment, but there was no significant difference between the two groups.

Conclusion: Three months of Pentoxifylline treatment in combination with diet and exercise results in significantly greater reduction in AST levels in patients with NASH as compared with controls.

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Figures

Fig. 1
Fig. 1
Comparison of AST levels before and after treatment
Fig. 2
Fig. 2
Comparison of ALT levels before and after treatment
See this image and copyright information in PMC

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1053/jhep.2002.32483', 'is_inner': False, 'url': 'https://doi.org/10.1053/jhep.2002.32483'}, {'type': 'PubMed', 'value': '11915019', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11915019/'}]}
    2. Younossi ZM, Diehl AM, Ong JP. Nonalcoholic fatty liver disease: an agenda for clinical research. Hepatology. 2002;35:743–52. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1053/jhep.2002.30692', 'is_inner': False, 'url': 'https://doi.org/10.1053/jhep.2002.30692'}, {'type': 'PubMed', 'value': '11826411', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11826411/'}]}
    2. Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, et al. NASH and insulin resistance: insulin hypersecretion and specific association with insulin resistance syndrome. Hepatology. 2002;35:373–9. - PubMed
    1. None
    2. Hill D, Shedolfsy F, McClain CJ, Diehl DM, Tsukamoto H. Cytokines and liver disease. In: Remick D, Freidland J, editors. Cytokines in health and disease. 2nd ed. New York: Marcel Dekker, 1997. p. 401–25.
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '10422201', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10422201/'}]}
    2. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis. 1999;19:205–19. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '11078773', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11078773/'}]}
    2. Tigl H, Diehl AM. Cytokines in alcoholic and non alcoholic steatohepatitis. N Engl J Med. 2000;343:467–76. - PubMed

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