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. 2008 Dec;2(4):429-39.
doi: 10.1007/s12072-008-9096-8. Epub 2008 Sep 5.

Primary prophylaxis of gastroesophageal variceal bleeding: consensus recommendations of the Asian Pacific Association for the Study of the Liver

Shiv Kumar Sarin  1 , Ashish Kumar, Peter W Angus, Sanjay Saran Baijal, Yogesh Kumar Chawla, Radha Krishna Dhiman, H Janaka de Silva, Saeed Hamid, Shozo Hirota, Ming-Chih Hou, Wasim Jafri, Mobin Khan, Laurentius A Lesmana, Hock F Lui, Veena Malhotra, Hitoshi Maruyama, Debendranath Guha Mazumder, Masao Omata, Ujjal Poddar, Amrinder S Puri, Praveen Sharma, Huma Qureshi, Rizvi Moattar Raza, Peush Sahni, Puja Sakhuja, Mohammad Salih, Amal Santra, Barjesh Chander Sharma, Hasnain Ali Shah, Gamal Shiha, Jose Sollano; APASL Working Party on Portal Hypertension
Affiliations

Primary prophylaxis of gastroesophageal variceal bleeding: consensus recommendations of the Asian Pacific Association for the Study of the Liver

Shiv Kumar Sarin et al. Hepatol Int. 2008 Dec.

Abstract

The Asian Pacific Association for the Study of the Liver (APASL) set up a Working Party on Portal Hypertension in 2002, with a mandate to develop consensus guidelines on various clinical aspects of portal hypertension relevant to disease patterns and clinical practice in the Asia-Pacific region. Variceal bleeding is a consequence of portal hypertension, which, in turn, is the major complication of liver cirrhosis. Primary prophylaxis to prevent the first bleed from varices is one of the most important strategies for reducing the mortality in cirrhotic patients. Experts predominantly from the Asia-Pacific region were requested to identify the different aspects of primary prophylaxis and develop the consensus guidelines. The APASL Working Party on Portal Hypertension evaluated the various therapies that have been used for the prevention of first variceal bleeding. A 2-day meeting was held on January 12 and 13, 2007, at New Delhi, India, to discuss and finalize the consensus statements. Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and were subsequently presented at the annual conference of the APASL at Kyoto, Japan, in March 2007.

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