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. 1990 Jul;32(3):109-12.

Soluble CD8 antigen in systemic sclerosis

G Famularo  1 , R Giacomelli, S Sacchetti, C Danese, A M Luciani, M A Perego, G Tonietti
Affiliations
  • PMID: 1966946

Soluble CD8 antigen in systemic sclerosis

G Famularo et al. J Clin Lab Immunol. 1990 Jul.

Abstract

In 15 patients suffering from systemic sclerosis (PSS) the function of CD8+ circulating lymphocytes was assayed by determining soluble CD8 antigen (sCD8) both in sera and in 48 hr PHA-conditioned media of peripheral blood mononuclear cells (PBMCs). Furthermore, the frequency of circulating activated CD8+ cells, which express DR antigens, interleukin-2 receptor, and transferrin-receptor, was determined by cytofluorographic analysis. The results of this preliminary study indicate that only in 6 PSS sera sCD8 was elevated as compared to healthy controls; furthermore, we found slightly increased sCD8 in culture media from PSS patients. The frequency of circulating activated CD8+ cells was similar both in PSS patients and in controls. Overall, our findings suggest that CD8+ cell activation is not a major phenomenon in PSS.

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