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. 2009 Apr;25(2):207-10.
doi: 10.4103/0970-1591.52916.

Impact of age and gender on the clinicopathological characteristics of bladder cancer

Parag Gupta  1 , Manoj Jain, Rakesh Kapoor, K Muruganandham, Aneesh Srivastava, Anil Mandhani
Affiliations

Impact of age and gender on the clinicopathological characteristics of bladder cancer

Parag Gupta et al. Indian J Urol. 2009 Apr.

Abstract

Purpose: To determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India.

Materials and methods: From January 2001 to June 2008, records of patients with bladder cancer were evaluated for age and gender at presentation, clinical symptoms, cystoscopic finding, history of smoking, and histopathological characteristics. A total of 561 patients were identified from the computer-based hospital information system and the case files of patients.

Results: A total of 97% of the patients presented with painless hematuria. The mean age was 60.2 +/- 4.4 years old (range: 18-90 years old) and the male to female ratio was 8.6:1. Transitional cell carcinoma (TCC) was the most common histological variety, which was present in 97.71% (470 of 481) of the patients. A total of 26% of the patients had muscle invasive disease at the time of presentation. However, 34.5% (166 of 481) of the patients did not show any evidence of detrusor muscle in their biopsy specimen. In patients with nonmuscle-invasive bladder carcinoma, 55% had p Ta while 45% had p T1. Overall, 44.7% (215 of 481) of the patients had low-grade disease. Among patients younger than 60 years old, low-grade (51.0% vs. 38.1%; P = 0.006) and low-stage (77.1% vs. 70.8%; P = 0.119) disease were more prevalent than in patients older than 60 years old. The incidence of smoking was much higher among males compared with females (74% vs. 22%).

Conclusion: TCC is the predominant cancer, with significant male preponderance among Indian patients. Younger-aged patients have low-grade disease. Hematuria is the most common presentation and greater awareness is needed not to overlook bladder cancer.

Keywords: Age; bladder cancer; gender; smoking; transitional cell carcinoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Age distribution of bladder tumors
See this image and copyright information in PMC

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