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Clinical Trial
. 1990 Jan 13;335(8681):63-6.
doi: 10.1016/0140-6736(90)90536-e.

Effects of physical training in chronic heart failure

Affiliations
Clinical Trial

Effects of physical training in chronic heart failure

A J Coats et al. Lancet. .

Abstract

Eleven patients with chronic heart failure secondary to ischaemic heart disease (mean [SEM] age 63.0 [2.3] years; left ventricular ejection fraction 19 [8]% undertook 8 weeks of home-based bicycle exercise training and 8 weeks of activity restriction (rest) in a physician-blind, random-order, crossover trial. Training increased exercise duration from 14.2 (1.1) min to 16.8 (1.3) min and peak oxygen consumption from 14.3 (1.1) ml.min-1.kg-1 to 16.7 (1.3) ml.min-1.kg-1. Heart rates at submaximum workloads and rate-pressure products were significantly reduced by training, and there was also a significant improvement in patient-rated symptom scores. No adverse events occurred during the training phase. Thus home-based physical training programmes are feasible even in severe chronic heart failure and have a beneficial effect on exercise tolerance, peak oxygen consumption, and symptoms. The commonly held belief that rest is the mainstay of treatment of chronic heart failure should no longer be accepted.

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Comment in

  • Monitoring compliance in clinical trials.
    Kruse W, Schlierf G, Weber E. Kruse W, et al. Lancet. 1990 Mar 31;335(8692):803-4. doi: 10.1016/0140-6736(90)90929-y. Lancet. 1990. PMID: 1969555 Clinical Trial. No abstract available.

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