First case of disseminated Mycobacterium bolletii infection in a young adult patient

Abstract

Mycobacterium bolletii is a rapidly growing nontuberculous mycobacterium first characterized in 2006. Here, we report a case of disseminated infection caused by M. bolletii in a young adult patient. To our knowledge, this is the first case of disseminated M. bolletii infection in an otherwise healthy young adult.

FIG. 1.

Twenty-three-year-old man with disseminated Mycobacterium bolletii infection. (A) A contrast-enhanced chest CT scan obtained at the level of the carina by using the mediastinal window setting shows extensive mediastinal lymphadenopathy. Note the bilateral pleural effusion. (B) A chest CT scan obtained using the lung window setting shows multiple pulmonary nodules. (C) After 4 weeks of antibiotic therapy, the chest lesions, including the mediastinal lymphadenopathy and parenchymal nodules, were improved. Also note the disappearance of the bilateral pleural effusion.

FIG. 2.

Phylogenetic positions of isolate Samsung 194 and RGM species, based on the partial RNA polymerase ß subunit gene (rpoB) (A) and the partial heat shock protein 65 gene (hsp65) (B). This tree was constructed using the neighbor-joining method. The percentages indicated at the nodes represent bootstrap levels supported by 1,000 resampled data sets. Bootstrap values of <50% are not shown. The solid circle indicates that the corresponding nodes (groupings) were also recovered in the maximum-parsimony trees. Mycobacterium tuberculosis was used as the outgroup species. Scale bars represent differences in nucleotide sequences.