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Review
. 2009 Aug:24:245-9.
doi: 10.1152/physiol.00009.2009.

What's new about osmotic regulation of glycerophosphocholine

Morgan Gallazzini  1 , Maurice B Burg
Affiliations
Review

What's new about osmotic regulation of glycerophosphocholine

Morgan Gallazzini et al. Physiology (Bethesda). 2009 Aug.

Abstract

Glycerophosphocholine is an abundant renal medullary organic osmolyte that protects renal medullary cells from the high interstitial concentrations of NaCl and urea to which they are normally exposed. We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance.

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Figures

FIGURE 1
FIGURE 1. Metabolism of glycerophosphocholine
Both NTE and GDPD5 are osmotically regulated.
See this image and copyright information in PMC

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