doi: 10.1039/b910500j.
Epub 2009 Jul 9.
The influence of catechol structure on the suicide-inactivation of tyrosinase
Affiliations
- PMID: 19675891
- DOI: 10.1039/b910500j
Item in Clipboard
The influence of catechol structure on the suicide-inactivation of tyrosinase
Org Biomol Chem.
.
Abstract
3,6-Difluorocatechol, which cannot act as a monooxygenase tyrosinase substrate, is an oxidase substrate, and, in contrast to other catechols, oxidation does not lead to suicide-inactivation, providing experimental evidence for an inactivation mechanism involving reductive elimination of Cu(0) from the active site.
Similar articles
-
Mechanistic studies of the inactivation of tyrosinase by resorcinol.Bioorg Med Chem. 2013 Mar 1;21(5):1166-73. doi: 10.1016/j.bmc.2012.12.031. Epub 2013 Jan 3. Bioorg Med Chem. 2013. PMID: 23352755
-
Tyrosinase: the four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation.Bioorg Med Chem. 2014 Apr 15;22(8):2388-95. doi: 10.1016/j.bmc.2014.02.048. Epub 2014 Mar 4. Bioorg Med Chem. 2014. PMID: 24656803 Review.
-
Evidence consistent with the requirement of cresolase activity for suicide inactivation of tyrosinase.Tohoku J Exp Med. 2008 Nov;216(3):231-8. doi: 10.1620/tjem.216.231. Tohoku J Exp Med. 2008. PMID: 18987457
-
The mechanism of suicide-inactivation of tyrosinase: a substrate structure investigation.Tohoku J Exp Med. 2007 Aug;212(4):341-8. doi: 10.1620/tjem.212.341. Tohoku J Exp Med. 2007. PMID: 17660699
-
New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins.Pigment Cell Melanoma Res. 2009 Dec;22(6):750-60. doi: 10.1111/j.1755-148X.2009.00636.x. Epub 2009 Sep 7. Pigment Cell Melanoma Res. 2009. PMID: 19735457 Review.
Cited by
-
Structure-function correlations in tyrosinases.Protein Sci. 2015 Sep;24(9):1360-9. doi: 10.1002/pro.2734. Epub 2015 Jul 7. Protein Sci. 2015. PMID: 26104241 Free PMC article. Review.
-
Latent and active aurone synthase from petals of C. grandiflora: a polyphenol oxidase with unique characteristics.Planta. 2015 Sep;242(3):519-37. doi: 10.1007/s00425-015-2261-0. Epub 2015 Feb 20. Planta. 2015. PMID: 25697287 Free PMC article.
-
The mechanism of copper uptake by tyrosinase from Bacillus megaterium.J Biol Inorg Chem. 2013 Dec;18(8):895-903. doi: 10.1007/s00775-013-1034-0. Epub 2013 Sep 6. J Biol Inorg Chem. 2013. PMID: 24061559
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
