Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009;47(3):262-7.
doi: 10.1515/cclm.2009.061.

Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease

Kym McNicholas  1 , Tong Chen, Catherine A Abbott
Affiliations
Review

Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease

Kym McNicholas et al. Clin Chem Lab Med. 2009.

Abstract

Dipeptidyl peptidase (DP) 6 and DP10 are non-enzyme members of the dipeptidyl peptidase IV family, which includes fibroblast activation protein, DP8, and DP9. DP6 and DP10 proteins have been shown to be critical components of voltage-gated potassium (Kv) channels important in determining cellular excitability. The aim of this paper was to review the research to date on DP6 and DP10 structure, expression, and functions. To date, the protein region responsible for modulating Kv4 channels has not been conclusively identified and the significance of the splice variants has not been resolved. Resolution of these issues will improve our overall knowledge of DP6 and DP10 and lead to a better understanding of their role in diseases, such as asthma and Alzheimer's disease.

PubMed Disclaimer

MeSH terms