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. 1977 Aug;11(4):837-43.
doi: 10.1016/0092-8674(77)90295-1.

The early region of SV40 DNA may have more than one gene

B Thimmappaya, S M Weissman

The early region of SV40 DNA may have more than one gene

B Thimmappaya et al. Cell. 1977 Aug.

Abstract

The nucleotide sequence of 70 base pairs (bp) around 0.545 map units (Alu I C and B junction) of the genome from the single Eco RI cleavage site within SV40 DNA is presented. The mRNA transcribed from the early strand template from this stretch contains two copies of the nonsense triplet UAA in each of the three reading frames. Thus at least 25% of the early region of SV40 DNA does not code for the SV40 "A" protein, and the viral contribution to events in the lytic cycle and transformation may be more complex than is generally appreciated.

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