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Review
. 1990 Feb 1;343(6257):425-30.
doi: 10.1038/343425a0.

Regulation of the mevalonate pathway

J L Goldstein  1 , M S Brown
Affiliations
Review

Regulation of the mevalonate pathway

J L Goldstein et al. Nature. .

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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